A new chapter in Cardinals history began in April 2006 when the team christened Busch Stadium. For more than five decades fans have been attending games at different Busch Stadiums as the Cardinals have moved into new ballparks. Throughout the late 1990s the Cardinals began lobbying for a new ballpark to replace old Busch Stadium. Like nearly every team in baseball the owners of the team wanted a new ballpark to bring in additional revenues from luxury and club seats. Although many fans were sad to see old Busch Stadium demolished, a new chapter in Cardinals history will occur at the new Busch Stadium with many new memories.

For nearly four years the Cardinals struggled to obtain financial assistance from the city in order to construct Busch Stadium. In June 2001, the Cardinals and the State of Missouri signed a contract to build a new ballpark in downtown St. Louis, adjacent to their old ballpark. Busch Stadium is owned by the Cardinals and was privately financed using a combination of private bonds that the Cardinals are required to repay, bank loans, cash from the owners of the Cardinals and a long-term loan from St. Louis County. In August 2004, the Cardinals and Anheuser-Busch agreed on a 20 year contract to keep the Busch Stadium name alive. Construction of Busch Stadium began in December 2003 with official groundbreaking ceremonies occurring on January 17, 2004.

On April 10, 2006 the St. Louis Cardinals made their debut at Busch Stadium against the Milwaukee Brewers. As fans approach the ballpark many past the old site of Busch Stadium and enter on the field level. The facade of the ballpark consists of brick and steel, with arched openings at the main entrances, with the arches reminisce of nearby warehouses. For the first half of the season, a small section of Busch Stadium in left field was not complete. Construction of this section was not able to begin until the old Busch Stadium was demolished. By July 2006, Busch Stadium was complete and has a seating capacity of 46,700.